ACCEL Lite: Featured ACCEL Interviews on Exciting CV Research
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ACCEL Lite: Featured ACCEL Interviews on Exciting CV Research
The American College of Cardiology offers select interviews and summaries of cardiology’s most interesting research areas from ACCEL’s renowned library, hosted by ACCEL Editor-in-Chief Alison L. Bailey, MD, FACC, FAACPVR.
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DAPT-SHOCK-AMI Trial: Cangrelor in Cardiogenic Shock
The DAPT SHOCK AMI trial is the first major study to evaluate antiplatelet therapy specifically in patients with cardiogenic shock (CS) following acut...
ODYSSEY-HCM: Mavacamten in nHCM
The ODYSSEY-HCM trial found that mavacamten did not significantly improve exercise capacity or patient-reported outcomes in individuals with symptomat...
DAN-RSV: RSVpreF Vaccine for Preventing Cardiorespiratory Hospitalizations
The DAN-RSV trial is one of the largest individually randomized studies ever conducted, enrolling over 131,000 participants aged 60 and older to evalu...
The Role of Prevention During and After Reproduction
Adverse pregnancy outcomes (APOs), affecting up to 20% of pregnancies, serve as early indicators of a woman’s future cardiovascular risk and should be...
The Role of Imaging in Cardiovascular Prevention
Cohort studies have provided robust data on cardiovascular risk factors, forming the basis for predictive models like the Pooled Cohort Equations and...
Improving Cardiovascular Clinical Competencies Menopausal Transition
The menopause transition marks a pivotal period of cardiometabolic change that significantly elevates cardiovascular (CV) risk in women. Despite its c...
Behind the 2025 ACC/AHA Acute Coronary Syndrome Guideline
The 2025 ACC/AHA Acute Coronary Syndrome guideline is the first major update since 2013, incorporating a decade of new evidence and clinical insights....
Top Takeaways From the 2025 ACC/AHA Acute Coronary Syndrome Guideline
The 2025 ACC/AHA Acute Coronary Syndrome (ACS) Guideline clarifies diagnostic distinctions using electrocardiogram changes, troponin levels, and imagi...
Risk vs. Benefit in Chronic Total Occlusion Revascularization
Chronic Total Occlusion Percutaneous Coronary Intervention (CTO PCI) is a procedure used to open coronary arteries that have been completely blocked f...
LAAO vs. DOAC for Stroke Prevention in AFib
While blood thinners like warfarin and direct oral anticoagulants (DOACs) remain the standard for stroke prophylaxis, left atrial appendage occlusion...
Why Are They Still Dyspneic? Post PE Syndrome Workup and Management
Persistent symptoms after an acute pulmonary embolism (PE) may indicate post-pulmonary embolism syndrome (PPES), a condition affecting up to 50% of pa...
Palliative Care Across the Spectrum of Biological Age in Heart Failure
Palliative care supports heart failure patients by guiding complex medical decisions, managing symptoms, and enhancing quality of life. Despite being...
ACCEL Lite: Hypertension Diagnosis and Management: Renal Denervation and Newer Agents on the Horizon
Recent clinical trials demonstrate that intensive blood pressure lowering—targeting systolic levels below 120 mm Hg—can significantly reduce cardiovas...
What's the Best Time to Revascularize the Non-culprit Lesions in MVD
Rapid emergency medical services transport to a percutaneous coronary intervention (PCI)-capable hospital is critical for timely intervention and mana...
Putting it All Together: Cardiogenic Shock Management in 2025
Cardiogenic shock remains a critical, time-sensitive emergency with a high mortality rate. However, recent advances—particularly multidisciplinary, te...
Hemodynamic Assessment for Diagnosis and Treatment Selection in HFpEF
Heart failure arises when the heart is unable to pump or fill with blood effectively. In the cardiac catheterization lab, we have the unique ability t...
Primary Results From the SOUL Randomized Trial
The SOUL trial demonstrated that in patients with type 2 diabetes (T2DM) and established atherosclerotic cardiovascular disease (ASCVD), chronic kidne...
Clopidogrel Versus Aspirin For Long-term Maintenance Monotherapy In Patients With High Ischemic Risk After PCI
The SMART-CHOICE 3 trial demonstrated that clopidogrel monotherapy is more effective than aspirin monotherapy in reducing the risk of major adverse ca...
Dapagliflozin in Patients Undergoing Transcatheter Aortic Valve Implantation
The DapaTAVI trial, conducted across 39 centers in Spain, is the first study to evaluate the use of sodium-glucose co-transporter-2 (SGLT-2) inhibito...
PRAGUE-25 Trial: Catheter Ablation Versus Antiarrhythmic Drugs With Risk Factor Modification for Treatment of AF
The PRAGUE-25 study evaluated the effectiveness of two treatment strategies in patients with both atrial fibrillation (AF) and obesity: catheter abla...
Lifetime Benefit by Control of Modifiable Risk Factors
A Global Cardiovascular Risk Consortium study of nearly 2 million people worldwide found that avoiding five modifiable risk factors—hypertension, hype...
ZENITH Phase 3 Trial: Sotatercept in Pulmonary Arterial Hypertension With High Mortality Risk
The ZENITH trial evaluated sotatercept, an activin signaling inhibitor, in patients with advanced pulmonary arterial hypertension (PAH) at high risk o...
Cardiac Arrest During Long-Distance Running Races: 2010-2023
The “Cardiac Arrest During Long-Distance Running Races: 2010–2023” study analyzed the incidence and outcomes of sudden cardiac arrests (SCAs) occurrin...
WARRIOR Trial: Outcomes to Reduce Events in Non-Obstructive Coronary Artery Disease
Funded by the Congressionally Directed Medical Research Programs (CDMRP) of the Department of Defense, the WARRIOR (Women's IschemiA TRial to Reduce e...
STRIDE Trial: Effects of Semaglutide in Patients With Peripheral Artery Disease
Patients with peripheral artery disease (PAD) often experience significant walking difficulties, and there are limited therapies available to improve...
Evolut Low-Risk Trial: 5-year Data Outcomes
Transcatheter aortic valve replacement (TAVR) has emerged as the preferred treatment for aortic stenosis. However, there is a lack of long-term outcom...
FRESH-UP Study: Liberal Fluid Intake Versus Fluid Restriction in Chronic Heart Failure
Fluid restriction is often recommended for heart failure (HF) patients to prevent congestion, but its benefits and safety are unclear. The FRESH-UP st...
Chronic Thromboembolic Pulmonary Hypertension (CTEPH): Procedures or Pills?
Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare and potentially fatal form of elevated blood pressure in the lungs. CTEPH treatment ov...
A Look at The 2024 AHA/ACC Perioperative Guideline s
The 2024 American Heart Association/American College of Cardiology (AHA/ACC)/multisociety guideline for perioperative cardiovascular (CV) management f...
The Evolving Therapeutic Landscape in Obesity and the Effect on CV Outcomes
In this interview, Drs. Richard Chazal and Mikhail Kosiborod explore the rapidly evolving therapeutic landscape of obesity, with a particular focus on...
Getting the Most Out of ChatGPT and Other Large Language Models in Cardiology
Drafting messages, summarizing charts, managing appointments, and assessing eligibility are all tasks that large language models can streamline. Howev...
How Low and How Fast Should We Go with LDL Cholesterol?
A personalized approach to lowering cholesterol is crucial in preventing heart attacks, as the optimal level, speed, and duration of low-density lipop...
Incidental Coronary Artery Calcium: Opportunistic Screening of Prior Non-gated Chest CTs To Improve Statin Rates
Notifying patients and their clinicians about incidental coronary calcium findings can encourage shared decision-making on preventive therapies and si...
Pulmonary Hypertension Associated with Left Heart Disease: Clinical Presentations, Implications for the RV and Treatment Target
Pulmonary hypertension (PH) is most commonly linked to left heart disease (LHD). The 7th World Symposium on Pulmonary Hypertension PH-LHD task force r...
Cardiovascular Health, CKM Syndrome and CVD Risk: Putting It All Together
Three complementary constructs ̶ cardiovascular health, cardiovascular-kidney-metabolic (CKM) syndrome, and cardiovascular disease (CVD) risk asse...
Artificial Intelligence-based Automated ECHOcardiographic Measurements and the Workflow of Sonographers (AI-ECHO): Randomized Crossover Trial
The use of artificial intelligence (AI) assistance in echocardiography is proving beneficial in a multitude of ways: significantly reducing time per e...
Implications for Ablation Outcomes: Results from the ARREST-AF Trial
In this episode, Drs. Joseph Marine and Rajeev Pathak dive into the ARREST-AF trial and its implications for ablation outcomes in atrial fibrillation...
Tools of the Trade for HCM: Update in Diagnosis and Management Strategies of a Common Cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is generally an inherited global heart disease in which only a fraction of those with the condition are clinically d...
The Role of Advanced Lipid Testing in 2024
Advanced lipid testing holds significant potential in cardiovascular care by enhancing risk prediction beyond standard lipid panels. For patients, thi...
SUMMIT Trial: Tirzepatide for Heart Failure, Preserved Ejection Fraction and Obesity
he SUMMIT trial compared the safety and efficacy of tirzepatide among patients with heart failure with preserved ejection fraction (HFpEF) and obesity...